Sunday, July 14, 2013

After Being Rejected By Y Combinator, This 26-Year-Old Landed Twitter's Biz Stone As A Mentor

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You could be forgiven for thinking that a certain someone doesn't know what they're talking about. Mars urges you not to sit around waiting for things to happen, so put yourself in different situations, participate in a range of activities, and circulate among a wide variety of people to attract the opportunity you're looking for. Be selective about what you believe, and if in doubt check the facts first.

Source: http://www.topix.com/business/financial-services/2013/07/after-being-rejected-by-y-combinator-this-26-year-old-landed-twitters-biz-stone-as-a-mentor?fromrss=1

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Monday, July 1, 2013

Too much of a good thing? Too many 'healing' cells delays wound healing

Too much of a good thing? Too many 'healing' cells delays wound healing [ Back to EurekAlert! ] Public release date: 1-Jul-2013
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Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology

New research published in the Journal of Leukocyte Biology suggests that delayed wound healing in lymphedematous skin results from too many mast cells which leads to elevated IL-10 expression

Bethesda, MD -- Like most other things, you can have too much of a good thing when it comes to wound healing, and new research proves it. According to an article published in the July 2013 issue of the Journal of Leukocyte Biology, wound healing can be delayed because the body produces too many mast cells, which normally promote healing. An overabundance of these cells, however, also causes harm by leading to the overproduction of IL-10, which prevents certain white blood cells from reaching the wounded area. The work was conducted in mice with lymphedematous skin, and may one day provide better treatments for elderly individuals with skin ulcers in the lower extremities, for women with upper-extremity wounds following breast cancer surgery, and skin wounds of any type that are not healing as they should.

"Improvement of lymphedema is important for treatment of skin ulcers," said Makoto Sugaya, M.D., Ph.D., a researcher involved in the work from the Department of Dermatology at the University of Tokyo in Tokyo, Japan. "It is not just fluid retention, but inflammatory cells and cytokines that cause delayed wound healing."

To make this discovery, scientists used two groups of mice. The first group showed severe lymphatic dysfunction. The second group was normal. Researchers administered skin wounds and found that the mice with lymphatic dysfunction showed delayed would healing as compared to the normal mice. Analysis showed that the delayed would healing in the lymphedematous skin is the result of too many mast cells and elevated IL-10 expression, both of which can now be therapeutic targets for future drug development.

"Wound healing is something most people take for granted until there's a problem," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "However, wound healing is a complex process involving immune as well as non-immune cells and problems that arise can be very serious, even if it started as a minor wound. This report provides an immunological explanation for why some wound healing is delayed, and it ultimately may help set a course for therapies that accelerate wound healing."

###

The Journal of Leukocyte Biology (publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. The Journal of Leukocyte Biology is published by the Society for Leukocyte Biology.

Details: Takayuki Kimura, Makoto Sugaya, Andrew Blauvelt, Hitoshi Okochi, and Shinichi Sato. Delayed wound healing due to increased interleukin-10 expression in mice with lymphatic dysfunction. J Leukoc Biol July 2013 94:137-145; doi:10.1189/jlb.0812408; http://www.jleukbio.org/content/94/1/137.abstract


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Too much of a good thing? Too many 'healing' cells delays wound healing [ Back to EurekAlert! ] Public release date: 1-Jul-2013
[ | E-mail | Share Share ]

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology

New research published in the Journal of Leukocyte Biology suggests that delayed wound healing in lymphedematous skin results from too many mast cells which leads to elevated IL-10 expression

Bethesda, MD -- Like most other things, you can have too much of a good thing when it comes to wound healing, and new research proves it. According to an article published in the July 2013 issue of the Journal of Leukocyte Biology, wound healing can be delayed because the body produces too many mast cells, which normally promote healing. An overabundance of these cells, however, also causes harm by leading to the overproduction of IL-10, which prevents certain white blood cells from reaching the wounded area. The work was conducted in mice with lymphedematous skin, and may one day provide better treatments for elderly individuals with skin ulcers in the lower extremities, for women with upper-extremity wounds following breast cancer surgery, and skin wounds of any type that are not healing as they should.

"Improvement of lymphedema is important for treatment of skin ulcers," said Makoto Sugaya, M.D., Ph.D., a researcher involved in the work from the Department of Dermatology at the University of Tokyo in Tokyo, Japan. "It is not just fluid retention, but inflammatory cells and cytokines that cause delayed wound healing."

To make this discovery, scientists used two groups of mice. The first group showed severe lymphatic dysfunction. The second group was normal. Researchers administered skin wounds and found that the mice with lymphatic dysfunction showed delayed would healing as compared to the normal mice. Analysis showed that the delayed would healing in the lymphedematous skin is the result of too many mast cells and elevated IL-10 expression, both of which can now be therapeutic targets for future drug development.

"Wound healing is something most people take for granted until there's a problem," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "However, wound healing is a complex process involving immune as well as non-immune cells and problems that arise can be very serious, even if it started as a minor wound. This report provides an immunological explanation for why some wound healing is delayed, and it ultimately may help set a course for therapies that accelerate wound healing."

###

The Journal of Leukocyte Biology (publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. The Journal of Leukocyte Biology is published by the Society for Leukocyte Biology.

Details: Takayuki Kimura, Makoto Sugaya, Andrew Blauvelt, Hitoshi Okochi, and Shinichi Sato. Delayed wound healing due to increased interleukin-10 expression in mice with lymphatic dysfunction. J Leukoc Biol July 2013 94:137-145; doi:10.1189/jlb.0812408; http://www.jleukbio.org/content/94/1/137.abstract


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-07/foas-tmo070113.php

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Utah Valley University ready to reap benefits as member of Western Athletic Conference

UVU President Matthew S. Holland announces Utah Valley University as the newest member of the Western Athletic Conference at the UCCU Center on the campus of Utah Valley University in Orem, Utah Tuesday Oct. 9, 2012.

August Miller, Utah Valley University Marketing

Enlarge photo?

OREM ? Bereft of automatic bids to NCAA postseason tournaments, UVU's best was never good enough.

Now, with the clout of the Western Athletic Conference behind them, the Wolverines are ready for the change they've dreamed of for years.

Utah Valley University officially joins the WAC on Monday, a move that obliterates the last obstacle between the school and a level playing field with the rest of the NCAA's Division I programs.

"It's (like) when you're getting ready to take your free throw and everybody's watching, or hitting the putt on the 18th green, (or) before the puck dropped in Game 6 (of the Stanley Cup Finals)," said soon-to-be athletic director Vince Otoupal. "It's a really nervous excitement."

Otoupal won't officially start guiding UVU into its new WAC era until his official starting date of July 15, but his comments already mirror those of the coaches and players within the Wolverines' athletic department.

"It legitimizes everything we've done and do at Utah Valley University," said men's basketball coach Dick Hunsaker. "I certainly feel a great amount of responsibility to be able to put together a competitive team on the court."

Self-imposed pressure shouldn't be expected or required ? UVU has gone from being a community college to a state college to an NCAA, conference-aligned Division I school in just 25 years ? but the athletic administration, coaches and players are all in agreement about one thing.

They don't want to waste any time cashing in on the new benefits that come packaged with their new conference.

"I think overall, everyone is very excited about the chance at an automatic bid to go to an NCAA tournament," men's basketball center Ben Aird said. "I think that's a huge draw."

Hunsaker, who watched stars like Ryan Toolson, Ronnie Price and Isiah Williams enjoy stellar careers without having opportunities on bigger stages, concurred with Aird.

"We've been waiting for a long, long time to get in an AQ conference," Hunsaker said. "To be in the WAC with its brand name, it's going to take on a special meaning. This inaugural season will be one to remember."

The "brand-name" factor, along with wins, is what UVU hopes will draw increased local recognition. Game attendance has been sporadic, often depending on the quality of visiting opponents (such as Penn State wrestling or Arizona baseball) or record-breaking winning streaks (such as baseball's in 2012 or men's basketball in 2011).

"You look at BYU and Utah State or (other schools) who have been in the WAC in previous years, that kind of set that foundation of being a conference that's recognizable to people," Aird said. "It's going to help bring the community together with greater support for UVU athletics because people will say 'Oh, they're in the WAC. We know what that conference is.' They're going to want to come out to games more; they're going to want to be more involved."

The turnaround from the Great West to WAC could be as harsh as it is exciting. Hunsaker admitted the recruiting window was small to prepare for the transition.

Like the rest of UVU's athletic teams in 2013-14, however, Hunsaker said his team will roll with it, ready or not.

"We've not had time to recruit to the WAC and an automatic conference, but as they say, 'ready, steady, go.'"

Matt Petersen is the Sports Web Editor for DeseretNews.com. You can follow him on Twitter at @TheMattPetersen.

Source: http://www.deseretnews.com/article/865582434/Utah-Valley-University-ready-to-reap-benefits-as-member-of-Western-Athletic-Conference.html

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San Francisco transit talks resume, strike looms

OAKLAND, Calif. (AP) ? With a Sunday night deadline approaching, negotiations between the San Francisco Bay Area Rapid Transit and two of its largest unions have intensified with a possible strike at stake.

As the parties went back to the bargaining table Saturday in Oakland for anticipated around-the-clock sessions, both sides described the talks as tense and said they're far apart on key sticking points including salary, pensions, health care and safety.

About 400,000 riders use BART, the nation's fifth largest rail system, on weekdays. A strike that could start as early as Monday would be chaotic for those commuters and affect every mode of transportation, clogging highways and bridges throughout the Bay Area.

BART said it has agreed to at least a handful of minor proposals from members of the Service Employees International Union (SEIU), Local 1021 and the Amalgamated Transit Union (ATU), Local 1555, but not on the major issues.

BART spokesman Rick Rice said that while talks were stagnant after the agency offered employees a new contract proposal on Thursday, he said both parties were talking by midday Saturday. On Friday, a mediator exchanged proposals between the parties who did not meet.

Rice said he expects long discussions right down to Sunday's deadline.

"Nobody wants a strike," ATU local president Antonette Bryant said Saturday. "We are prepared to spend the night ? a couple of nights ? in order to finally reach a deal."

The unions want a 5 percent annual raise over the next three years. BART said Saturday that train operators and station agents in the unions average about $71,000 in base salary and $11,000 in overtime annually. The workers also pay a flat $92 monthly fee for health insurance.

Meanwhile, BART has offered a 1 percent raise annually over the next four years and for employees to contribute to their pensions.

The unions' current contract expires at midnight Sunday. On Friday, the ATU asked California Gov. Jerry Brown to issue a 60-day "cooling off" period if no deal can be reached by Sunday's deadline, but the SEIU and BART officials have urged Brown not to issue such an order.

The governor's office has declined to comment.

"Negotiations are frustrating," Rice said. "But, we'll be here, no matter long it takes. We're committed to work this out."

BART's last strike lasted six days in 1997. On Friday, other area transit agencies urged commuters to consider carpooling, taking buses or ferries, working from home and, if they must drive to work, to leave earlier or even later than usual.

"The bottom line is that a BART strike will be an absolute nightmare for everyone," said Jim Wunderman, president and CEO of the Bay Area Council, a business advocacy organization. "Our transportation system simply does not have the capacity to absorb the more than 400,000 BART riders who will be left at the station. There will be serious pain."

Source: http://news.yahoo.com/san-francisco-transit-talks-resume-strike-looms-230845272.html

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Confed Cup Live: AP follows the final day action

An indigenous man gestures in front of Maracana stadium prior to the soccer Confederations Cup final between Brazil and Spain in Rio de Janeiro, Brazil, Sunday, June 30, 2013. (AP Photo/Tales Azzoni)

An indigenous man gestures in front of Maracana stadium prior to the soccer Confederations Cup final between Brazil and Spain in Rio de Janeiro, Brazil, Sunday, June 30, 2013. (AP Photo/Tales Azzoni)

A fan of Uruguay waits for the start of the soccer Confederations Cup third-place match between Uruguay and Italy at the Fonte Nova stadium in Salvador, Brazil, Sunday, June 30, 2013. (AP Photo/Fernando Llano)

(AP) ? The Associated Press is following events in Rio de Janeiro on Sunday. The Confederations Cup final between Spain and Brazil starts at 6 p.m. EDT. Follow this live feed for updates:

___

THIRD PLACE

Italy leads Uruguay 1-0 at halftime in Salvador in the third-place match at the Confederations Cup. The goal was scored by Davide Astori. The ball appeared to go into the net off the back of Uruguay goalkeeper Fernando Muslera after a free kick from Alessandro Diamanti hit the post in the 24th minute. Diamanti originally was credited as the scorer, but the FIFA website now says it was Astori.

Uruguay lost to Brazil in the semifinals, and Italy was beaten by Spain in a penalty shootout. Cesare Prandelli, the coach of Italy, has complained about the third-place match, calling for FIFA to review whether it's needed. The Italians are upset because they have had only two days to rest since Thursday's draining loss; Uruguay last played on Wednesday. Another cause of contention is the start time. The third-place match is the only game of this tournament to start at 1 p.m., when it can be quite warm in Brazil, especially up north in Salvador.

___

SITTING THIS ONE OUT

Mariela Simao, a 22-year-old biotechnology student who lives near Maracana Stadium, has decided to sit this one out ? both Sunday's protest and the Confederations Cup final. Simao, who first took the streets about two weeks ago when many Brazilians let their rage spill over into violence while calling for government reforms, tells AP's Rob Harris that she is staying behind this time because she is afraid of the police.

"They are not only looking at the people doing bad stuff, breaking windows, they are shooting everyone indiscriminately," Simao said, referring to police firing rubber bullets and tear gas. She also said she loves soccer and supports Brazil's national team, which will be facing Spain in the final of the World Cup warmup tournament, but she is now more concerned about other problems in the country. "I hope they are champions," Simao said, "but the country needed to invest in a lot of things before bringing the World Cup here ? hospitals, schools."

___

POLICE HALT PROTESTERS

Protesters marching toward the stadium for the Confederations Cup final have been stopped on Avenida do Maracana by a battalion of military police carrying shields, AP's Jenny Barchfield says. There are also busloads of police reinforcements nearby in case of violence. Standing in front of a line of police and yelling at them is a middle-aged woman with a T-shirt that says "Grandma." Protesters have taken to the streets all over Brazil in the past two weeks, calling for a wide range of reforms.

Some of their ire has been targeted at the high cost of staging next year's World Cup and the 2016 Olympics. Brazilian police told AP's Tales Azzoni that they would allow people to protest outside Maracana Stadium as long as the demonstrations were peaceful. People without tickets usually are not allowed near the venue in FIFA tournaments, but the Maracana sits in a crowded Rio neighborhood and authorities said they would not keep local residents away from the venue.

A few civil law enforcement officers and an elite police unit were in front of the main entrance, so far just watching the demonstrators. A handful of people were calling for attention to human trafficking, and others complained of poor conditions at Rio de Janeiro hospitals. "We want better conditions in the health services in Rio," said 59-year-old Geralda Ramos, who works at a local hospital. "We need to speak up because the government is not paying attention to us. We need better salaries and better equipment to be able to treat our people."

___

SOCCER, TANKS, RIOT GEAR

A crowd of protesters has started to make its way from Saenz Pena, a square not far from central Rio, and is heading for the Maracana, says AP's Jenny Barchfield. Once they get near the stadium, they'll find officers in riot gear and tanks awaiting them. If there is going to be a violent standoff, it's likely to occur there. The tournament has been marked by violent anti-government protests, partly aimed at the high cost of staging next year's World Cup. Several thousand police have been put on alert, but as of noon in Rio, only a few hundred people had gathered in the center of the city, according to Barchfield. Outside the stadium, a handful of protesters held banners saying, "How much is silence worth?"

___

DRESSED IN YELLOW

Brazilian fans are out on the streets in force, many wearing the team's traditional yellow. In the country that will host next year's World Cup, soccer is indeed serious, and the match against world champion Spain may be one to remember. Brazil's national team has been rebuilding under coach Luiz Felipe Scolari, man who led the team to its fifth and last World Cup title in 2002. But the team has so far met Scolari's expectations, winning all four of its matches to reach the final. Spain made it through by beating Italy in a penalty shootout in the semifinals, and could even be considered the underdog for the match since it will be played at Maracana, Brazil's most renowned soccer venue.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-06-30-SOC-Confed-Cup-Running/id-de00421e2b3a4ace859471b642415c09

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Wainwright ties for NL lead with 11 wins

By JANIE McCAULEY

AP Baseball Writer

Associated Press Sports

updated 7:15 p.m. ET June 29, 2013

OAKLAND, Calif. (AP) - This time, Adam Wainwright left little doubt he should stay on the mound and keep pitching.

Mike Matheny let him go, even when things became a bit dicey in the eighth.

Wainwright tossed a five-hitter to become the NL's second 11-game winner, Matt Adams had his first two-homer game, and the St. Louis Cardinals beat the Oakland Athletics 7-1 Saturday.

Wainwright (11-5) tied Washington's Jordan Zimmerman for most wins in the NL. He struck out eight and walked two in a 112-pitch performance for his fourth complete game this year and 15th of his career.

"I came out very focused and executed my plan for the most part," he said. "I had the two late walks that kind of chapped me. Any time you're going late in the game like that giving yourself a chance to win, your team a chance to win, that's what you want. Every starter's goal is when you start the game to throw the last pitch of the game, too."

Wainwright appeared to have no issues Saturday after objecting to manager Mike Matheny's decision to pull him after 6 2-3 innings in a loss to Texas last Sunday. When Wainwright got into an eighth-inning jam and gave up Josh Reddick's RBI single, Matheny stuck with him - and might have still if another batter had reached. They would have at least had a conversation about it.

"He was laboring from the first, and you can tell him I said that," Matheny joked Saturday, repeating his words from last week that fired up the pitcher.

To which Wainwright offered: "Yeah, I was laboring. Laboring means working, right? I was working."

Wainwright knew how well the A's have been playing at home, and became determined to slow down the reigning AL West champions. With his signature, moving curveball, he kept them off-balance all day.

"He had everything," Matheny said. "Mainly, he was very good at locating the fastball and using the curveball in different ways, different speeds, different breaks and making big pitches when he needed to."

What appeared a pitcher's duel in the making changed quickly when A's starter Jarrod Parker left in the fourth inning with tightness in his right hamstring on an unusually hot Bay Area afternoon.

Parker will be re-evaluated Sunday.

"He wanted to try to finish the inning but he still felt it," manager Bob Melvin said. "It's not a prudent thing to do. The unfortunate thing was that might have been as good as stuff as he's had all year. Had a great changeup, had great velocity on the fastball, good movement, good slider. We might have been here a while had that not happened."

Adams hit a three-run homer to highlight a four-run sixth and a solo shot in the eighth.

Matheny describes his unique "lofting power."

"I just use my size and leverage," said Adams, who is 6-foot-3 and 260 pounds. "I don't swing too hard. I get in trouble if I over-swing."

Daniel Descalso broke a scoreless tie with a sacrifice fly in the fifth, and the Cardinals gave Wainwright plenty of support to take sole possession of the team lead in wins ahead of Lance Lynn's 10.

After a 1-2-3 first inning on nine pitches, Wainwright was on his way. A's No. 9 hitter Derek Norris singled with two outs in the third for the first hit off Wainwright, who snapped a two-start skid.

Wainwright got through the seventh on seven pitches. The right-hander faced the A's for just the second time in his career after beating Oakland on June 19, 2010, in St. Louis while allowing one earned run in eight innings.

He had a career-high five complete games in 2010, and is now one away from that.

A sold-out Coliseum crowd of 35,067 braved the hot temperatures to watch Wainwright keep the A's batters off balance - they didn't get a three-ball count until Coco Crisp walked in the eighth as the 28th hitter of the game. Wainwright threw 21 of his pitches that inning.

While the first-pitch temperature was an A's season-high 84 degrees, Matheny is loving the lively atmosphere this series.

"It reminds me of the Dominican and Puerto Rico, a lot of drums and excitement," he said.

Parker went down after grabbing his right hamstring and stretching for several minutes with athletic trainer Nick Paparesta before throwing some warmup pitches. Jesse Chavez relieved.

"Tomorrow will be a better idea of what I've got," Parker said. "I've just been building on outings prior, and today everything was working good early."

Chavez (1-2), who pitched 5 2-3 scoreless innings of relief for victory in an 18-inning win against the Yankees on June 13, was done after 1 1-3 innings this time. Carlos Beltran doubled starting the sixth, and Allen Craig followed with a single to chase Chavez.

Jerry Blevins surrendered an RBI single to Matt Holliday, then Adams' first-pitch homer that broke open the game.

Holliday faced repeated boos while in left field and at the plate from his former fans. He briefly played for the A's in 2009, all of 93 games.

NOTES: The Cardinals are sticking with rookie Shelby Miller on schedule despite his struggles. "He's going to go back out there and do what he was doing," Matheny said. ... A's C John Jaso missed his seventh straight start with a cut on his left hand. ... A's C Stephen Vogt received 100-plus text messages in addition to greetings on Facebook and Twitter after his first major league hit - and home run - Friday night ended an 0-for-33 start. "It's really neat to get everybody's support," he said. ... Umpires received water between innings. ... Wainwright is 8-5 in interleague play. ... LHP Tommy Milone looks to snap a four-start winless stretch with his first win since June 3 in Sunday's finale against St. Louis RHP Jake Westbrook.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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